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1

High-throughput Generation of Synthetic Antibodies from Highly Functional Minimalist Phage-displayed Libraries

Frederic A. Fellouse, Kaori Esaki, Sara Birtalan, Demetrios Raptis, Vincenzo J. Cancasci, Akiko Koide, Parkash Jhurani, Mark Vasser, Christian Wiesmann, Anthony A. Kossiakoff, Shohei Koide, Sachdev S.

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 3.63 MB

english, 2007

2

The X-ray structure of a growth hormoneprolactin receptor complex

Somers, William, Ultsch, Mark, De Vos, Abraham M., Kossiakoff, Anthony A.

Journal:

Year:

1994

File:

PDF, 686 KB

1994

3

X-ray structure of human relaxin at 1·5Å: Comparison to insulin and implications for receptor binding determinants

Charles Eigenbrot, Michael Randal, Clifford Quan, John Burnier, Lori O'Connell, Ernst Rinderknecht, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 707 KB

english, 1991

4

The Application of Neutron Crystallography to the Study of Dynamic and Hydration Properties of Proteins

Kossiakoff, Anthony A.

Journal:

Annual Review of Biochemistry

Year:

1985

Language:

english

File:

PDF, 946 KB

english, 1985

5

X-ray Structure of Snow Flea Antifreeze Protein Determined by Racemic Crystallization of Synthetic Protein Enantiomers

Pentelute, Brad L., Gates, Zachary P., Tereshko, Valentina, Dashnau, Jennifer L., Vanderkooi, Jane M., Kossiakoff, Anthony A., Kent, Stephen B. H.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 1.34 MB

english, 2008

6

A YidC-like Protein in the Archaeal Plasma Membrane

Borowska, Marta T., Dominik, Pawel K., Anghel, S. Andrei, Kossiakoff, Anthony A., Keenan, Robert J.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.55 MB

english, 2015

7

Total Chemical Synthesis and X-ray Crystal Structure of a Protein Diastereomer: [D-Gln 35]Ubiquitin

Duhee Bang, George I. Makhatadze, Valentina Tereshko, Anthony A. Kossiakoff, Stephen B. Kent

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 691 KB

english, 2005

8

Time-Controlled Microfluidic Seeding in nL-Volume Droplets To Separate Nucleation and Growth Stages of Protein Crystallization

Cory J. Gerdts, Valentina Tereshko, Maneesh K. Yadav, Irina Dementieva, Frank Collart, Andrzej Joachimiak, Raymond C. Stevens, Peter Kuhn, Anthony Kossiakoff, Rustem F. Ismagilov

Journal:

Angewandte Chemie

Year:

2006

Language:

english

File:

PDF, 351 KB

english, 2006

9

Total Chemical Synthesis and X-ray Crystal Structure of a Protein Diastereomer: [D-Gln 35]Ubiquitin

Duhee Bang, George I. Makhatadze, Valentina Tereshko, Anthony A. Kossiakoff, Stephen B. Kent

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 691 KB

english, 2005

10

Time-Controlled Microfluidic Seeding in nL-Volume Droplets To Separate Nucleation and Growth Stages of Protein Crystallization

Cory J. Gerdts, Valentina Tereshko, Maneesh K. Yadav, Irina Dementieva, Frank Collart, Andrzej Joachimiak, Raymond C. Stevens, Peter Kuhn, Anthony Kossiakoff, Rustem F. Ismagilov

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 351 KB

english, 2006

11

The production and X-ray structure determination of perdeuterated Staphylococcal nuclease

Theresa R. Gamble, Karl R. Clauser, Anthony A. Kossiakoff

Journal:

Biophysical Chemistry

Year:

1994

Language:

english

File:

PDF, 1.18 MB

english, 1994

12

Structural consequences of mutation

Charles Eigenbrot, Anthony A. Kossiakoff

Journal:

Current Opinion in Biotechnology

Year:

1992

Language:

english

File:

PDF, 580 KB

english, 1992

13

Protein engineering. Editorial overview

Anthony Kossiakoff, Michael Smith

Journal:

Current Opinion in Biotechnology

Year:

1993

Language:

english

File:

PDF, 419 KB

english, 1993

14

Exploring and designing protein function with restricted diversity

Sachdev S Sidhu, Anthony A Kossiakoff

Journal:

Current Opinion in Chemical Biology

Year:

2007

Language:

english

File:

PDF, 699 KB

english, 2007

15

Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity

Mary A Dwyer, Wuyuan Lu, John J Dwyer, Anthony A Kossiakoff

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 234 KB

english, 2000

16

Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes

Wuyuan Lu, Michael Randal, Anthony Kossiakoff, Stephen B.H. Kent

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 963 KB

english, 1999

17

Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods

Kalyaneswar Mandal, Brad L. Pentelute, Valentina Tereshko, Vilasak Thammavongsa, Olaf Schneewind, Anthony A. Kossiakoff, Stephen B. H. Kent

Journal:

Protein Science

Year:

2009

Language:

english

File:

PDF, 577 KB

english, 2009

18

Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors

Anthony A. Kossiakoff, William Somers, Mark Ultsch, Kerrie Andow, Yves A. Muller, Abraham M. De Vos

Journal:

Protein Science

Year:

1994

Language:

english

File:

PDF, 10.82 MB

english, 1994

19

Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of alzheimer's amyloid β-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): Engineering of inhibitors with altered specificities

Axel J. Scheidig, Thomas R. Hynes, Laura A. Pelletier, James A. Wells, Anthony A. Kossiakoff

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 11.82 MB

english, 1997

20

The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold

Yang Qiu, Valentina Tereshko, Youngchang Kim, Rongguang Zhang, Frank Collart, Mohammed Yousef, Anthony Kossiakoff, Andrzej Joachimiak

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 480 KB

english, 2006

21

The 1.38 Å crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway

Yang Qiu, Rongguang Zhang, T. Andrew Binkowski, Valentina Tereshko, Andrzej Joachimiak, Anthony Kossiakoff

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2008

Language:

english

File:

PDF, 939 KB

english, 2008

22

Crystal structure of subtilisin BPN′ variants containing disulfide bonds and cavities: Concerted structural rearrangements induced by mutagenesis

Bradley Katz, Anthony A. Kossiakoff

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1990

Language:

english

File:

PDF, 1.38 MB

english, 1990

23

Analysis of solvent structure in proteins using neutron D2OH2O solvent maps: Pattern of primary and secondary hydration of trypsin

Anthony A. Kossiakoff, Michael D. Sintchak, Joseph Shpungin, Leonard G. Presta

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 1.26 MB

english, 1992

24

Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction

Janet S. Finer-Moore, Anthony A. Kossiakoff, James H. Hurley, Thomas Earnest, Dr. Robert M. Stroud

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 1.98 MB

english, 1992

25

Variability of conformations at crystal contacts in BPTI represent true low-energy structures: Correspondence among lattice packing and molecular dynamics structures

Anthony A. Kossiakoff, Michael Randal, Jeanmarie Guenot, Charles Eignebrot

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 970 KB

english, 1992

26

Structural effects induced by mutagenesis affected by crystal packing factors: The structure of a 30–51 disulfide mutant of basic pancreatic trypsin inhibitor

Charles Eigenbrot, Michael Randal, Anthony A. Kossiakoff

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 1.04 MB

english, 1992

27

10.1038/79063

Kossiakoff, Anthony A., Elkins, Patricia A., Christinger, Hans W., Sandowski, Yael, Sakal, Edna, Gertler, Arieh, de Vos, Abraham M.

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 279 KB

english, 2000

28

10.1038/79061

Kossiakoff, Anthony A., Elkins, Patricia A., Christinger, Hans W., Sandowski, Yael, Sakal, Edna, Gertler, Arieh, de Vos, Abraham M.

Journal:

Nature Genetics

Year:

2000

Language:

english

File:

PDF, 70 KB

english, 2000

29

10.1038/79047

Kossiakoff, Anthony A., Elkins, Patricia A., Christinger, Hans W., Sandowski, Yael, Sakal, Edna, Gertler, Arieh, de Vos, Abraham M.

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 547 KB

english, 2000

30

Dissecting the energetics of protein α-helix C-cap termination through chemical protein synthesis

Bang, Duhee, Gribenko, Alexey V, Tereshko, Valentina, Kossiakoff, Anthony A, Kent, Stephen B, Makhatadze, George I

Journal:

Nature Chemical Biology

Year:

2006

Language:

english

File:

PDF, 367 KB

english, 2006

31

A roadmap to generate renewable protein binders to the human proteome

Wojcik, John, Koide, Akiko, Kossiakoff, Anthony A, Koide, Shohei, Sidhu, Sachdev, Dyson, Michael R, Colwill, Karen, Persson, Helena, Jarvik, Nicholas E, Wyrzucki, Arkadiusz

Journal:

Year:

2011

Language:

english

File:

PDF, 1012 KB

english, 2011

32

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

Koldobskaya, Yelena, Duguid, Erica M, Shechner, David M, Suslov, Nikolai B, Ye, Jingdong, Sidhu, Sachdev S, Bartel, David P, Koide, Shohei, Kossiakoff, Anthony A, Piccirilli, Joseph A

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.45 MB

english, 2010

33

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins

Rizk, Shahir S, Paduch, Marcin, Heithaus, John H, Duguid, Erica M, Sandstrom, Andrew, Kossiakoff, Anthony A

Journal:

Nature Structural and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.14 MB

english, 2011

34

Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold

Valentina Tereshko, Serdar Uysal, Akiko Koide, Katrina Margalef, Shohei Koide, Anthony A. Kossiakoff

Journal:

Protein Science

Year:

2008

Language:

english

File:

PDF, 634 KB

english, 2008

35

Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis

Gábor Pál, Shun-Yin Fong, Anthony A. Kossiakoff, Sachdev S. Sidhu

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 348 KB

english, 2005

36

Understanding mechanisms governing protein–protein interactions from synthetic binding interfaces

Anthony A Kossiakoff, Shohei Koide

Journal:

Current Opinion in Structural Biology

Year:

2008

Language:

english

File:

PDF, 2.14 MB

english, 2008

37

Keeping Signaling in Check

Anthony A. Kossiakoff, Shahir Rizk

Journal:

Year:

2010

Language:

english

File:

PDF, 186 KB

english, 2010

38

The Structure and Activity of a Monomeric Interferon-γ:α-Chain Receptor Signaling Complex

Michael Randal, Anthony A. Kossiakoff

Journal:

Year:

2001

Language:

english

File:

PDF, 462 KB

english, 2001

39

X-ray Structures of the Antigen-binding Domains from Three Variants of Humanized anti-p185HER2 Antibody 4D5 and Comparison with Molecular Modeling

Charles Eigenbrot, Michael Randal, Leonard Presta, Paul Carter, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 1.78 MB

1993

40

The Crystal Structure of Affinity-matured Human Growth Hormone at 2 Å Resolution

Mark H. Ultsch, William Somers, Anthony A. Kossiakoff, Abraham M. de Vos

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 960 KB

1994

41

A Comparison of Neutron Diffraction and Molecular Dynamics Structures: Hydroxyl Group and Water Molecule Orientations in Trypsin

Robert S. McDowell, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 4.58 MB

english, 1995

42

Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites

Celia Schiffer, Mark Ultsch, Scott Walsh, William Somers, Abraham M de Vos, Anthony Kossiakoff

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 568 KB

english, 2002

43

Crystals of the complex between human growth hormone and the extracellular domain of its receptor

Mark Ultsch, Abraham M. de Vos, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 989 KB

english, 1991

44

Intramolecular Cooperativity in a Protein Binding Site Assessed by Combinatorial Shotgun Scanning Mutagenesis

Gábor Pál, Mark H. Ultsch, Kevin P. Clark, Bridget Currell, Anthony A. Kossiakoff, Sachdev S. Sidhu

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 610 KB

english, 2005

45

Crystal Structure and Site 1 Binding Energetics of Human Placental Lactogen

Scott T.R. Walsh, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 713 KB

english, 2006

46

Exploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat Paratope

Akiko Koide, Valentina Tereshko, Serdar Uysal, Katrina Margalef, Anthony A. Kossiakoff, Shohei Koide

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.32 MB

english, 2007

47

The Functional Binding Epitope of a High Affinity Variant of Human Growth Hormone Mapped by Shotgun Alanine-scanning Mutagenesis: Insights into the Mechanisms Responsible for Improved Affinity

Gabor Pal, Anthony A. Kossiakoff, Sachdev S. Sidhu

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 769 KB

english, 2003

48

The first semi-synthetic serine protease made by native chemical ligation

Gábor Pál, Fanny Santamaria, Anthony A Kossiakoff, Wuyuan Lu

Journal:

Protein Expression and Purification

Year:

2003

Language:

english

File:

PDF, 175 KB

english, 2003

49

Generating conformation-specific synthetic antibodies to trap proteins in selected functional states

Paduch, Marcin, Koide, Akiko, Uysal, Serdar, Rizk, Shahir S., Koide, Shohei, Kossiakoff, Anthony A.

Journal:

Year:

2013

Language:

english

File:

PDF, 735 KB

english, 2013

50

Generation of a De Novo Actin Pointed-End Binding Protein

Brawley, Crista M., Uysal, Serdar, Rizk, Shahir, Luchniak, Anna, Kossiakoff, Anthony, Rock, Ronald S.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 31 KB

english, 2010